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AMPA-R Removal Underlies Aβ-induced Synaptic Depression and Dendritic Spine Loss
Beta amyloid (Aβ), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer’s Disease. Recent studies indicate that this peptide can drive loss of surface AMPA and NMDA type glutamate receptors. We now show that Aβ emplo...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850952/ https://ncbi.nlm.nih.gov/pubmed/17145504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2006.10.035 |
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