Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis

Pancreatic stellate cells mediate fibrosis in chronic pancreatitis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs)-1 and -2 are crucial modulators of fibrosis. Transforming growth factor-β (TGF-β) is a key regulator of extracellular matrix production and myofibr...

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Autori principali: Shek, Fanny Wai-Tsing, Benyon, Robert Christopher, Walker, Fiona Mairi, McCrudden, Peter Raymond, Pender, Sylvia Lin Foon, Williams, Elizabeth Jean, Johnson, Penelope Ann, Johnson, Colin David, Bateman, Adrian Calvin, Fine, David Roger, Iredale, John Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850856/
https://ncbi.nlm.nih.gov/pubmed/12000730
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