Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2

Proteinase-activated receptor (PAR)-2, a G-protein-coupled receptor for trypsin and mast cell tryptase, is highly expressed in the intestine. Luminal trypsin and tryptase are elevated in the colon of inflammatory bowel disease patients. We hypothesized that luminal proteinases activate PAR-2 and ind...

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Detalhes bibliográficos
Main Authors: Cenac, Nicolas, Coelho, Anne-Marie, Nguyen, Cathy, Compton, Steven, Andrade-Gordon, Patricia, MacNaughton, Wallace K., Wallace, John L., Hollenberg, Morley D., Bunnett, Nigel W., Garcia-Villar, Rafael, Bueno, Lionel, Vergnolle, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850779/
https://ncbi.nlm.nih.gov/pubmed/12414536
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