Blockade of Platelet-Derived Growth Factor Receptor-β Pathway Induces Apoptosis of Vascular Endothelial Cells and Disrupts Glomerular Capillary Formation in Neonatal Mice

Platelet-derived growth factor (PDGF), a potent chemotactic and proliferation factor for mesenchymal-derived cells, has been demonstrated to play critical roles in kidney development. Two receptors for PDGF, PDGFR-α and PDGFR-β, have been identified and we previously analyzed the effects of blockade...

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Hauptverfasser: Sano, Hideto, Ueda, Yukihiko, Takakura, Nobuyuki, Takemura, Genzou, Doi, Toshio, Kataoka, Hiroshi, Murayama, Toshinori, Xu, Yang, Sudo, Tetsuo, Nishikawa, Satomi, Nishikawa, Shin-Ichi, Fujiwara, Hisayoshi, Kita, Toru, Yokode, Masayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850709/
https://ncbi.nlm.nih.gov/pubmed/12107098
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