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Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants

Fgf8 and Tbx1 have been shown to interact in patterning the aortic arch, and both genes are required in formation and growth of the outflow tract of the heart. However, the nature of the interaction of the two genes is unclear. We have utilized a novel Tbx1(Fgf8) allele which drives Fgf8 expression...

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Bibliographische Detailangaben
Hauptverfasser: Vitelli, Francesca, Zhang, Zhen, Huynh, Tuong, Sobotka, Angela, Mupo, Annalisa, Baldini, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850621/
https://ncbi.nlm.nih.gov/pubmed/16696966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2006.03.044
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