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Plasminogen Deficiency Leads to Impaired Lobular Reorganization and Matrix Accumulation after Chronic Liver Injury

To determine the regulatory role of plasminogen in hepatic repair following a chronic liver injury, we injected carbon tetrachloride (CCl(4)) biweekly into mice lacking plasminogen (Plg0) and plasminogen-sufficient littermates (Plg(+)). On gross examination, we found that Plg0 livers became enlarged...

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Detalhes bibliográficos
Main Authors: Pohl, John F., Melin-Aldana, Hector, Sabla, Gregg, Degen, Jay L., Bezerra, Jorge A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850588/
https://ncbi.nlm.nih.gov/pubmed/11733368
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