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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor

BACKGROUND: The urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin. Based on the efficient activation of plasminogen when uPA is bound to its receptor (uPAR) and on the role of...

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Bibliografiske detaljer
Main Authors: Shanmukhappa, Kumar, Sabla, Gregg E, Degen, Jay L, Bezerra, Jorge A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697812/
https://ncbi.nlm.nih.gov/pubmed/17134505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-6-40
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