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Direct Thrombin Inhibition Reduces Lung Collagen, Accumulation, and Connective Tissue Growth Factor mRNA Levels in Bleomycin-Induced Pulmonary Fibrosis

Dramatic activation of the coagulation cascade has been extensively documented for pulmonary fibrosis associated with acute and chronic lung injury. In addition to its role in hemostasis, thrombin exerts profibrotic effects via activation of the major thrombin receptor, protease-activated receptor-1...

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Autori principali: Howell, David C. J., Goldsack, Neil R., Marshall, Richard P., McAnulty, Robin J., Starke, Richard, Purdy, Gordon, Laurent, Geoffrey J., Chambers, Rachel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850500/
https://ncbi.nlm.nih.gov/pubmed/11583966
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