Direct Thrombin Inhibition Reduces Lung Collagen, Accumulation, and Connective Tissue Growth Factor mRNA Levels in Bleomycin-Induced Pulmonary Fibrosis

Dramatic activation of the coagulation cascade has been extensively documented for pulmonary fibrosis associated with acute and chronic lung injury. In addition to its role in hemostasis, thrombin exerts profibrotic effects via activation of the major thrombin receptor, protease-activated receptor-1...

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Detalhes bibliográficos
Main Authors: Howell, David C. J., Goldsack, Neil R., Marshall, Richard P., McAnulty, Robin J., Starke, Richard, Purdy, Gordon, Laurent, Geoffrey J., Chambers, Rachel C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850500/
https://ncbi.nlm.nih.gov/pubmed/11583966
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