Solution-Based Scanning for Single-Base Alterations Using a Double-Stranded DNA Binding Dye and Fluorescence-Melting Profiles

DNA molecules differing by as little as a single-base substitution have traditionally been distinguished by gel electrophoresis-based methodologies that exploit differences in the sequence-specific properties of double-stranded DNA (dsDNA) such as melting temperature and secondary conformational con...

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Bibliographic Details
Main Authors: Elenitoba-Johnson, Kojo S. J., Bohling, Sandra D.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2001
Subjects:
Technical Advances
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850450/
https://ncbi.nlm.nih.gov/pubmed/11549577
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