Mechanisms of β-Cell Death in Response to Double-Stranded (ds) RNA and Interferon-γ : dsRNA-Dependent Protein Kinase Apoptosis and Nitric Oxide-Dependent Necrosis

Viral infection is one environmental factor that has been implicated as a precipitating event that may initiate β-cell damage during the development of diabetes. This study examines the mechanisms by which the viral replicative intermediate, double-stranded (ds) RNA impairs β-cell function and induc...

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Hlavní autoři: Scarim, Anna L., Arnush, Marc, Blair, Libby A., Concepcion, Josephine, Heitmeier, Monique R., Scheuner, Donalyn, Kaufman, Randal J., Ryerse, Jan, Buller, R. Mark, Corbett, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2001
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850419/
https://ncbi.nlm.nih.gov/pubmed/11438474
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