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Staging of Neurofibrillary Degeneration Caused by Human Tau Overexpression in a Unique Cellular Model of Human Tauopathy

The hyperphosphorylation of human tau and its aggregation into neurofibrillary tangles are central pathogenic events in familial tauopathies and Alzheimer’s disease. However, the cellular consequences of neurofibrillary tangle formation in vivo have not been directly studied because cellular models...

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Autori principali: Hall, Garth F., Lee, Virginia M.-Y., Lee, Gloria, Yao, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850256/
https://ncbi.nlm.nih.gov/pubmed/11141497
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