p57(KIP2) Is Not Mutated in Hepatoblastoma but Shows Increased Transcriptional Activity in a Comparative Analysis of the Three Imprinted Genes p57(KIP2), IGF2, and H19

Hepatoblastomas (HBs), representing malignant liver tumors of childhood, show frequent loss of heterozygosity (LOH) in the chromosomal region 11p15.5. This loss is of maternal origin suggesting the presence of a monoallelically expressed tumor suppressor gene in this region. p57(KIP2) (KIP2) located...

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Detalhes bibliográficos
Main Authors: Hartmann, Wolfgang, Waha, Andreas, Koch, Arend, Goodyer, Cynthia G., Albrecht, Steffen, von Schweinitz, Dietrich, Pietsch, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
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Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850179/
https://ncbi.nlm.nih.gov/pubmed/11021841
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