Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation

A tumor suppressor gene at 10q 23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers. Germline mutations in PTEN cause Cowden syndrome (CS), which is chara...

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Détails bibliographiques
Auteurs principaux: Zhou, Xiao-Ping, Gimm, Oliver, Hampel, Heather, Niemann, Theodore, Walker, Michael J., Eng, Charis
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2000
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850161/
https://ncbi.nlm.nih.gov/pubmed/11021816
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