Germline and Somatic Mutation Analysis of MLH3 in MSI-Positive Colorectal Cancer

Microsatellite instability (MSI) is characteristic of hereditary nonpolyposis colorectal cancer, and occurs in a subset (10 to 15%) of unselected colorectal cancer cases. In hereditary nonpolyposis colorectal cancer, MSI is caused by defects in five mismatch repair genes, and in sporadic cases the m...

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Main Authors: Loukola, Anu, Vilkki, Susa, Singh, Jaskiran, Launonen, Virpi, Aaltonen, Lauri A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2000
Teme:
Short Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850126/
https://ncbi.nlm.nih.gov/pubmed/10934138
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