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Detection of Gene Amplification in Archival Breast Cancer Specimens by Laser-Assisted Microdissection and Quantitative Real-Time Polymerase Chain Reaction

Gene amplification is one of the most important mechanisms leading to deregulated gene expression in cancer. The exact quantitative detection of this frequent genomic alteration in solid tumors is often hampered by an admixture of nonneoplastic bystander and stroma cells. To overcome this obstacle a...

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Autors principals: Lehmann, Ulrich, Glöckner, Sabine, Kleeberger, Wolfram, von Wasielewski, Henning Feist Reinhard, Kreipe, Hans
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850085/
https://ncbi.nlm.nih.gov/pubmed/10854209
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