Dextran Sulfate Sodium-Induced Colonic Histopathology, but not Altered Epithelial Ion Transport, Is Reduced by Inhibition of Phosphodiesterase Activity

Inhibition of phosphodiesterase (PDE) activity is beneficial in models of arthritis and airway inflammation. Here we assessed the ability of PDE inhibitors to modulate colitis by exposing mice to 4% (w/v) dextran sulfate sodium (DSS) drinking water for 5 days with or without rolipram, an inhibitor o...

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Autors principals: Diaz-Granados, Natalia, Howe, Kathryn, Lu, Jun, McKay, Derek M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2000
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850075/
https://ncbi.nlm.nih.gov/pubmed/10854237
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