Mutations and Allelic Deletions of the MEN1 Gene Are Associated with a Subset of Sporadic Endocrine Pancreatic and Neuroendocrine Tumors and Not Restricted to Foregut Neoplasms

Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the frequency of allelic deletions and mutations of the recently identified MEN1 gene in 53 sporadic tumors including 30 EPT and...

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Hlavní autoři: Görtz, Birgit, Roth, Jürgen, Krähenmann, Akiko, de Krijger, Ronald R., Muletta-Feurer, Seraina, Rütimann, Katrin, Saremaslani, Parvin, Speel, Ernst J. M., Heitz, Philipp U., Komminoth, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 1999
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1849990/
https://ncbi.nlm.nih.gov/pubmed/10027401
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