Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

Systematic genome-wide studies to map genomic regions associated with human diseases are becoming more practical. Increasingly, efforts will be focused on the identification of the specific functional variants responsible for the disease. The challenges of identifying causal variants include the nee...

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Bibliografische gegevens
Hoofdauteurs: Graham, Robert R., Kyogoku, Chieko, Sigurdsson, Snaevar, Vlasova, Irina A., Davies, Leela R. L., Baechler, Emily C., Plenge, Robert M., Koeuth, Thearith, Ortmann, Ward A., Hom, Geoffrey, Bauer, Jason W., Gillett, Clarence, Burtt, Noel, Cunninghame Graham, Deborah S., Onofrio, Robert, Petri, Michelle, Gunnarsson, Iva, Svenungsson, Elisabet, Rönnblom, Lars, Nordmark, Gunnel, Gregersen, Peter K., Moser, Kathy, Gaffney, Patrick M., Criswell, Lindsey A., Vyse, Timothy J., Syvänen, Ann-Christine, Bohjanen, Paul R., Daly, Mark J., Behrens, Timothy W., Altshuler, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847749/
https://ncbi.nlm.nih.gov/pubmed/17412832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701266104
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