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An alternative branch of the nonsense-mediated decay pathway
The T-cell receptor (TCR) locus undergoes programmed rearrangements that frequently generate premature termination codons (PTCs). The PTC-bearing transcripts derived from such nonproductively rearranged genes are dramatically downregulated by the nonsense-mediated decay (NMD) pathway. Here, we show...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1847659/ https://ncbi.nlm.nih.gov/pubmed/17363904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601628 |
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