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Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption

The T-cell receptor (TCR) and immunoglobulin (Ig) genes are unique among vertebrate genes in that they undergo programmed rearrangement, a process that allows them to generate an enormous array of receptors with different antigen specificities. While crucial for immune function, this rearrangement m...

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Hlavní autoři: Imam, J. Saadi, Gudikote, Jayanthi P., Chan, Wai-kin, Wilkinson, Miles F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836556/
https://ncbi.nlm.nih.gov/pubmed/20007599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1115
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