An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline

BACKGROUND: The ubiquitin-proteasome system is responsible for homeostatic degradation of intact protein substrates as well as the elimination of damaged or misfolded proteins that might otherwise aggregate. During ageing there is a decline in proteasome activity and an increase in aggregated protei...

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Bibliographic Details
Main Authors: Proctor, Carole J, Tsirigotis, Maria, Gray, Douglas A
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847462/
https://ncbi.nlm.nih.gov/pubmed/17408507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-1-17
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