The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis

Human protective protein/cathepsin A (PPCA), a serine carboxypeptidase, forms a multienzyme complex with β-galactosidase and neuraminidase and is required for the intralysosomal activity and stability of these two glycosidases. Genetic lesions in PPCA lead to a deficiency of β-galactosidase and neur...

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Bibliographic Details
Main Authors: Rudenko, Gabby, Bonten, Erik, Hol, Wim. G. J., d’Azzo, Alessandra
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18470/
https://ncbi.nlm.nih.gov/pubmed/9435242
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