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Effect of methylprednisolone on entry of ampicillin and gentamicin into cerebrospinal fluid in experimental pneumococcal and Escherichia coli meningitis.

The influence of methylprednisolone on the passage of ampicillin and gentamicin into and activity within cerebrospinal fluid was examined in two models of experimental meningitis. Steroid pretreatment reduced the concentrations of these drugs in purulent cerebrospinal fluid of rabbits with experimen...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Scheld, W M, Brodeur, J P
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1983
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC184626/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6338816/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.1.108
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