Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

BACKGROUND: XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and – independent means. Loss of XAF1 expression through promoter methylation has been implicated in the process of tumorigenesis in a variety of cancers. In...

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Detalhes bibliográficos
Main Authors: Micali, O Cristina, Cheung, Herman H, Plenchette, Stéphanie, Hurley, Sandra L, Liston, Peter, LaCasse, Eric C, Korneluk, Robert G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1845166/
https://ncbi.nlm.nih.gov/pubmed/17376236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-52
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