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Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

The polyketides are a diverse group of natural products with great significance as human and veterinary pharmaceuticals. A significant barrier to the production of novel genetically engineered polyketides has been the lack of available heterologous expression systems for functional polyketide syntha...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kealey, James T., Liu, Lu, Santi, Daniel V., Betlach, Mary C., Barr, Philip J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18449/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435221/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.2.505
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