B-lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages

In mice, zygotic or pro-B-cell-specific knock-out of the Pax5 gene allows differentiation of pro-B-cells into all hematopoietic lineages. We previously generated and characterized a murine B-cell lymphoma, dubbed Myc5, whose cells spontaneously lose Pax5 expression when cultured in vitro, but regain...

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Hauptverfasser: Hodawadekar, Suchita, Yu, Duonan, Cozma, Diana, Freedman, Bruce, Sunyer, Oriol, Atchison, Michael L., Thomas-Tikhonenko, Andrei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839943/
https://ncbi.nlm.nih.gov/pubmed/17098231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2006.10.015
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