Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

The osteocyte, a terminally differentiated cell comprising 90%–95% of all bone cells1,2, may have multiple functions, including acting as a mechanosensor in bone (re)modeling3. Dentin matrix protein 1 (encoded by DMP1) is highly expressed in osteocytes4 and, when deleted in mice, results in a hypomi...

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Bibliografiska uppgifter
Huvudupphovsmän: Feng, Jian Q, Ward, Leanne M, Liu, Shiguang, Lu, Yongbo, Xie, Yixia, Yuan, Baozhi, Yu, Xijie, Rauch, Frank, Davis, Siobhan I, Zhang, Shubin, Rios, Hector, Drezner, Marc K, Quarles, L Darryl, Bonewald, Lynda F, White, Kenneth E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839871/
https://ncbi.nlm.nih.gov/pubmed/17033621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1905
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