Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α

The failure to expand functional pancreatic β-cell mass in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing β-cells is the principle mechanism for β-cell expansion in adult mice. Here we demonstrate that the prolif...

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Bibliografiska uppgifter
Huvudupphovsmän: Gupta, Rana K., Gao, Nan, Gorski, Regina K., White, Peter, Hardy, Olga T., Rafiq, Kiran, Brestelli, John E., Chen, Guang, Stoeckert, Christian J., Kaestner, Klaus H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2007
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838528/
https://ncbi.nlm.nih.gov/pubmed/17403778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1535507
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