Haplotype Association between Haptoglobin (Hp2) and Hp Promoter SNP (A-61C) May Explain Previous Controversy of Haptoglobin and Malaria Protection

BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations–despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the c...

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Main Authors: Cox, Sharon E., Doherty, Conor, Atkinson, Sarah H., Nweneka, Chidi V., Fulford, Anthony J.C., Ghattas, Hala, Rockett, Kirk A., Kwiatkowski, Dominic P., Prentice, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838521/
https://ncbi.nlm.nih.gov/pubmed/17426810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000362
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