Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria.

Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalos...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Bush, K, Freudenberger, J S, Sykes, R B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1982
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC183759/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6982680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.22.3.414
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