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Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria.

Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalos...

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Detalhes bibliográficos
Main Authors: Bush, K, Freudenberger, J S, Sykes, R B
Formato: Artigo
Idioma:Inglês
Publicado em: 1982
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC183759/
https://ncbi.nlm.nih.gov/pubmed/6982680
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