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INSULIN-LIKE GROWTH FACTOR (IGF)-I AMELIORATES DEMYELINATION INDUCED BY TUMOR NECROSIS FACTOR (TNF)-α IN TRANSGENIC MICE

Our laboratories have reported that TNF-α causes myelin damage and apoptosis of oligodendrocytes and their precursors in vitro and in vivo. We also have reported that IGF-I can protect cultured oligodendrocytes and their precursors from TNF-α-induced damage. In this study, we investigated whether IG...

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Detalhes bibliográficos
Main Authors: Ye, Ping, Kollias, George, D’Ercole, A. Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1832145/
https://ncbi.nlm.nih.gov/pubmed/17279553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.21181
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