Up-regulation of expression and lack of 5' CpG island hypermethylation of p16 INK4a in HPV-positive cervical carcinomas

BACKGROUND: High risk type human papilloma viruses (HR-HPV) induce carcinomas of the uterine cervix by expressing viral oncogenes E6 and E7. Oncogene E7 of HR-HPV disrupts the pRb/E2F interaction, which negatively regulates the S phase entry. Expression of tumor suppressor p16(ink4a )drastically inc...

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Hoofdauteurs: Ivanova, Tatiana A, Golovina, Daria A, Zavalishina, Larisa E, Volgareva, Galina M, Katargin, Alexey N, Andreeva, Yulia Y, Frank, Georgy A, Kisseljov, Fjodor L, Kisseljova, Natalia P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2007
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831478/
https://ncbi.nlm.nih.gov/pubmed/17359536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-47
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