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Identification of the sites of deoxyhaemoglobin PEGylation

The 2-iminothiolane reaction with protein amino groups adds a spacer arm ending with a thiol group, which can be further treated with molecules carrying a maleimido ring. This approach is currently used for the preparation of a candidate ‘blood substitute’ in which human Hb (haemoglobin) is conjugat...

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Detalhes bibliográficos
Main Authors: Iafelice, Roberto, Cristoni, Simone, Caccia, Dario, Russo, Rosaria, Rossi-Bernardi, Luigi, Lowe, Kenneth C., Perrella, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828880/
https://ncbi.nlm.nih.gov/pubmed/17155933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061556
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