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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a “soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1828602/ https://ncbi.nlm.nih.gov/pubmed/15922018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2005.01.001 |
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