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Expression of PPARα modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice
AIMS/HYPOTHESIS: In uncoupling protein-2 (UCP2) knockout (KO) mice, protection of beta cells from fatty acid exposure is dependent upon transcriptional events mediated by peroxisome proliferator-activated receptor-α (PPARα). METHODS: PPARα expression was reduced in isolated islets from UCP2KO and wi...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1828157/ https://ncbi.nlm.nih.gov/pubmed/17341307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-4-6 |
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