In vivo Administration of D609 Leads to Protection of Subsequently Isolated Gerbil Brain Mitochondria Subjected to In vitro Oxidative Stress Induced by Amyloid Beta-peptide and Other Oxidative Stressors: Relevance to Alzheimer’s Disease and Other Oxidative Stress-Related Neurodegenerative Disorders.

Tricyclodecan-9-yl-xanthogenate (D609) has in vivo and in vitro antioxidant properties. D609 mimics glutathione (GSH), has a free thiol group, which upon oxidation forms a disulfide. The resulting dixanthate is a substrate for glutathione reductase, regenerating D609. Recent studies have also shown...

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Detalhes bibliográficos
Main Authors: Ansari, Mubeen Ahmad, Joshi, Gururaj, Huang, Quanzhen, Opii, Wycliffe O., Abdul, Hafiz Mohmmad, Sultana, Rukhsana, Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1827074/
https://ncbi.nlm.nih.gov/pubmed/17145558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.09.002
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