Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Increased production of reactive oxygen species and loss of endothelial NO bioactivity are key features of vascular disease states such as diabetes mellitus. Tetrahydrobiopterin (BH4) is a required cofactor for eNOS activity; pharmacologic studies suggest that BH4 may mediate some of the adverse eff...

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Hauptverfasser: Alp, Nicholas J., Mussa, Shafi, Khoo, Jeffrey, Cai, Shijie, Guzik, Tomasz, Jefferson, Andrew, Goh, Nicky, Rockett, Kirk A., Channon, Keith M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC182196/
https://ncbi.nlm.nih.gov/pubmed/12952921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317786
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