Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice

BACKGROUND: Chronic hypoxia induces pulmonary arterial hypertension (PAH). Smooth muscle cell (SMC) proliferation and hypertrophy are important contributors to the remodeling that occurs in chronic hypoxic pulmonary vasculature. We hypothesized that rapamycin (RAPA), a potent cell cycle inhibitor, p...

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Detalhes bibliográficos
Main Authors: Paddenberg, Renate, Stieger, Philipp, von Lilien, Anna-Laura, Faulhammer, Petra, Goldenberg, Anna, Tillmanns, Harald H, Kummer, Wolfgang, Braun-Dullaeus, Ruediger C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821322/
https://ncbi.nlm.nih.gov/pubmed/17319968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-15
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