Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilat...

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Detalhes bibliográficos
Publicado no:Pulm Circ
Main Authors: Murtaza, Ghulam, Paddenberg, Renate, Pfeil, Uwe, Goldenberg, Anna, Mermer, Petra, Kummer, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Research Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236867/
https://ncbi.nlm.nih.gov/pubmed/30284509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045894018808240
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