Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration. In DMD mouse models and patients, we find that IκB kinase/NF-κB (IKK/NF-κB) signaling is persistently elevated in immune...

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Main Authors: Acharyya, Swarnali, Villalta, S. Armando, Bakkar, Nadine, Bupha-Intr, Tepmanas, Janssen, Paul M.L., Carathers, Micheal, Li, Zhi-Wei, Beg, Amer A., Ghosh, Sankar, Sahenk, Zarife, Weinstein, Michael, Gardner, Katherine L., Rafael-Fortney, Jill A., Karin, Michael, Tidball, James G., Baldwin, Albert S., Guttridge, Denis C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821069/
https://ncbi.nlm.nih.gov/pubmed/17380205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30556
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