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Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins

The 369-residue glycoprotein D (gD) is the entry, receptor-binding protein of herpes simplex virus 1. The common receptors for viral entry are nectin-1, HveA, and a specific O-linked sulfated proteoglycan. The major receptor-binding sites of gD are at the N terminus, whereas the domain required for...

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Bibliographic Details
Main Authors: Zhou, Guoying, Roizman, Bernard
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820722/
https://ncbi.nlm.nih.gov/pubmed/17360490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611565104
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