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X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is important in the control of oxidant stress in erythrocytes, the host cells for Plasmodium falciparum. Mutations in this enzyme produce X-linked deficiency states associated with protection against malaria, notably in Africa where the A− form of...

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Détails bibliographiques
Auteurs principaux: Guindo, Aldiouma, Fairhurst, Rick M, Doumbo, Ogobara K, Wellems, Thomas E, Diallo, Dapa A
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2007
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820604/
https://ncbi.nlm.nih.gov/pubmed/17355169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040066
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