High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance

BACKGROUND: Engagement of CD40 promotes survival of undifferentiated nasopharyngeal carcinoma (UNPC) cells and similar effects are induced by the EBV oncoprotein LMP-1 that is expressed in a fraction of cases. Considering that CD40 may be activated also by the soluble isoform of CD40L (sCD40L), we i...

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Bibliografiske detaljer
Main Authors: Caggiari, Laura, Guidoboni, Massimo, Vaccher, Emanuela, Barzan, Luigi, Franchin, Giovanni, Gloghini, Annunziata, Martorelli, Debora, Zancai, Paola, Bortolin, Maria Teresa, Mazzucato, Mario, Serraino, Diego, Carbone, Antonino, De Paoli, Paolo, Dolcetti, Riccardo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819365/
https://ncbi.nlm.nih.gov/pubmed/17331231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-9378-2-5
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