Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.

The pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin were determined in rabbits infected with Escherichia coli K1. After a single intravenous dose of 25 mg/kg, a peak N-formimidoyl thienamycin concentration in cerebrospinal fluid (CSF) of 2.5 micrograms/ml was attained at 4...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Patamasucon, P, McCracken, G H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1982
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7049073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.21.3.390
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