Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine or 7,8-dihydro-8-oxoguanine (8-OH-G). Products of the human MMH/OGG1 gene are known to catalyze in vitro the reactions repairing this DNA lesion. To analyze the function of Mmh in vivo, we genera...

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Detalhes bibliográficos
Main Authors: Minowa, Osamu, Arai, Tsuyoshi, Hirano, Masanori, Monden, Yoshiaki, Nakai, Shigeyasu, Fukuda, Mayuko, Itoh, Masaki, Takano, Hiroshi, Hippou, Yoshitaka, Aburatani, Hiroyuki, Masumura, Ken-ichi, Nohmi, Takehiko, Nishimura, Susumu, Noda, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18180/
https://ncbi.nlm.nih.gov/pubmed/10725358
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