Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

We have examined the function of a conserved serine residue (Ser670) in the S2 ligand-binding region of the NR2A N-methyl-d-aspartate (NMDA) receptor subunit, using recombinant NR1/NR2A receptors expressed in Xenopus laevis oocytes. Mutation of Ser670 to glycine (S670G) in NR2A reduced the potency o...

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Main Authors: Wyllie, David J A, Johnston, Alexander R, Lipscombe, Diane, Chen, Philip E
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Science Inc 2006
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817770/
https://ncbi.nlm.nih.gov/pubmed/16709630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.112193
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