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Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors
NR1/NR2D NMDA receptors display unusually slow deactivation kinetics which may be critical for their role as extrasynaptic receptors. A threonine to alanine point mutation has been inserted at amino acid position 692 of the NR2D subunit (T692A). Recombinant NR1a/NR2D(T692A) NMDA receptors have been...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
Blackwell Science Inc
2004
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664912/ https://ncbi.nlm.nih.gov/pubmed/15107472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.063800 |
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