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Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

NR1/NR2D NMDA receptors display unusually slow deactivation kinetics which may be critical for their role as extrasynaptic receptors. A threonine to alanine point mutation has been inserted at amino acid position 692 of the NR2D subunit (T692A). Recombinant NR1a/NR2D(T692A) NMDA receptors have been...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Philip E, Johnston, Alexander R, Selina Mok, MH, Schoepfer, Ralf, Wyllie, David JA
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664912/
https://ncbi.nlm.nih.gov/pubmed/15107472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.063800
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