Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

Fanconi anemia (FA) is a chromosome fragility syndrome characterized by bone marrow failure and cancer susceptibility. The central FA protein FANCD2 is known to relocate to chromatin upon DNA damage in a poorly understood process. Here, we have induced subnuclear accumulation of DNA damage to prove...

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Detalhes bibliográficos
Main Authors: Bogliolo, Massimo, Lyakhovich, Alex, Callén, Elsa, Castellà, Maria, Cappelli, Enrico, Ramírez, María J, Creus, Amadeu, Marcos, Ricard, Kalb, Reinhard, Neveling, Kornelia, Schindler, Detlev, Surrallés, Jordi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817623/
https://ncbi.nlm.nih.gov/pubmed/17304220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601574
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