Supercoiling affects the accessibility of glutathione to DNA-bound molecules: Positive supercoiling inhibits calicheamicin-induced DNA damage

DNA superhelical tension, an important feature of genomic organization, is known to affect the interactions of intercalating molecules with DNA. However, the effect of torsional tension on nonintercalative DNA-binding chemicals has received less attention. We demonstrate here that the enediyne calic...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	LaMarr, W. A., Yu, L., Nicolaou, K. C., Dedon, P. C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9419336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.1.102
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