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Leading and lagging strand DNA synthesis in vitro by a reconstituted herpes simplex virus type 1 replisome

The synthesis of double-stranded DNA by a rolling circle mechanism was reconstituted in vitro with a replisome consisting of the DNA polymerase-UL42 complex and the heterotrimeric helicase-primase encoded by herpes simplex virus type 1. Okazaki fragments 3 kilobases in length and leading strands tha...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Falkenberg, Maria, Lehman, I. R., Elias, Per
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10760262/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.8.3896
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